| 12:00 PM | Wisconsin @ 20 Penn State | ABC | Mark Jones, Dusty Dvoracek |
| 12:00 PM | Ole Miss @ Texas A&M | CBS | Carter Blackburn, Aaron Taylor, Rick Neuheisel |
| 12:00 PM | 10 Ohio State @ 18 Michigan State | FOX | Gus Johnson, Joel Klatt |
| 12:00 PM | South Carolina @ 15 Florida | ESPN | Dave Pasch, Greg McElroy, Tom Luginbill |
| 12:00 PM | Navy @ 12 UCF | ESPN2 | Anish Shroff, Ahmad Brooks |
| 12:00 PM | TCU @ 9 West Virginia | FS1 | Justin Kutcher, DeMarco Murray, Petros Papadakis |
| 12:00 PM | Tulsa @ Memphis | ESPNU | Mike Corey, Rene Ingoglia |
| 12:00 PM | Vanderbilt @ Missouri | SECN | Dave Neal, DJ Shockley |
| 12:00 PM | Illinois @ Nebraska | BTN | Brandon Gaudin, Glen Mason |
| 12:00 PM | Maryland @ Indiana | BTN | Lisa Byington, J Leman |
| 12:00 PM | Lafayette @ Army | CBSSN | Ben Holden, Jay Feely |
| 12:00 PM | Kansas @ Kansas State | FSN regional | Jeff Levering, Brian Baldinger |
| 12:00 PM | BYU vs Massachusetts
(in Foxboro) | Eleven, NESN, BYU TV | |
| 12:00 PM | Akron @ Eastern Michigan | ESPN3 | Dan Gutowsky, Bob Carpenter |
| 12:00 PM | Southern Methodist @ Connecticut | ESPN3 | Drew Fellios, Al Groh |
| 12:20 PM | North Carolina @ Duke | Raycom | Tom Werme, Dave Archer |
| 1:00 PM | Troy @ Georgia Southern | ESPN+ | |
| 2:00 PM | UCLA @ Arizona State | P12N | J.B Long, Anthony Herron |
| 2:30 PM | Charlotte @ Marshall | ESPN+ | |
| 3:00 PM | Liberty @ Virginia | ACC RSNs | Wes Durham, James Bates |
| 3:00 PM | Bowling Green @ Central Michigan | ESPN+ | |
| 3:00 PM | Middle Tennessee @ UTEP | ESPN+ | |
| 3:30 PM | Oklahoma State @ 6 Oklahoma | ABC | Steve Levy, Brian Griese, Todd McShay |
| 3:30 PM | 16 Mississippi State @ 1 Alabama | CBS | Brad Nessler, Gary Danielson |
| 3:30 PM | Northwestern @ 21 Iowa | FOX | Joe Davis, Brady Quinn |
| 3:30 PM | 8 Washington State @ Colorado | ESPN | Bob Wischusen, Brock Huard |
| 3:30 PM | Purdue @ Minnesota | ESPN2 | Beth Mowins, Anthony Becht, Rocky Boiman |
| 3:30 PM | Baylor @ 22 Iowa State | FS1 | Brian Custer, Ben Leber |
| 3:30 PM | Virginia Tech @ Pittsburgh | ESPNU | Kevin Brown, Andre Ware |
| 3:30 PM | 11 Kentucky @ Tennessee | SECN | Taylor Zarzour, John Congemi |
| 3:30 PM | 4 Michigan @ Rutgers | BTN | Kevin Kugler, James Laurinaitis |
| 3:30 PM | New Mexico @ Air Force | CBSSN | Rich Waltz, Aaron Murray |
| 3:30 PM | North Texas @ Old Dominion | ESPN3 | |
| 4:00 PM | East Carolina @ Tulane | ESPNEWS | Jay Alter, Dustin Fox |
| 4:00 PM | San Jose State @ Utah State | Stadium | |
| 4:00 PM | Appalachian State @ Texas State | KNVA CW Austin,
ESPN3 | |
| 5:00 PM | Western Kentucky @ Florida Atlantic | Stadium | |
| 5:00 PM | Arkansas State @ Coastal Carolina | ESPN+ | |
| 5:00 PM | Georgia State @ ULL | ESPN+ | |
| 5:00 PM | ULM @ South Alabama | ESPN+ | |
| 5:30 PM | Oregon @ Utah | P12N | Ted Robinson, Yogi Roth |
| 7:00 PM | 24 Auburn @ 5 Georgia | ESPN | Sean McDonough, Todd Blackledge |
| 7:00 PM | Miami (FL) @ Georgia Tech | ESPN2 | Clay Matvick, Dan Orlovsky |
| 7:00 PM | South Florida @ Cincinnati | ESPNU | Bill Roth, Mike Golic Jr. |
| 7:00 PM | Temple @ Houston | CBSSN | Dave Ryan, Randy Cross |
| 7:00 PM | Florida International @ UTSA | ESPN+ | |
| 7:00 PM | Rice @ Louisiana Tech | ESPN+ | |
| 7:30 PM | 19 Texas @ Texas Tech | FOX | Tim Brando, Spencer Tillman |
| 7:30 PM | Florida State @ 3 Notre Dame | NBC | Mike Tirico, Doug Flutie |
| 7:30 PM | 7 LSU @ Arkansas | SECN | Tom Hart, Jordan Rodgers, Cole Cubelic |
| 7:30 PM | Southern Mississippi @ UAB | BeIn Sports | Mike Gleason, Charles Arbuckle |
| 8:00 PM | 2 Clemson @ 17 Boston College | ABC | Chris Fowler, Kirk Herbstreit |
| 9:00 PM | Oregon State @ Stanford | P12N | Guy Haberman, Chad Brown |
| 10:30 PM | California @ USC | ESPN | Adam Amin, Rod Gilmore |
| 10:30 PM | UNLV @ San Diego State | ESPN2 | Mark Neely, Ray Bentley |
| 10:30 PM | Colorado State @ Nevada | ESPNU | Roy Philpott, Tom Ramsey |
