| 12:00 PM | 3 Clemson @ Louisville | ABC | Bob Wischusen, Dan Orlovsky |
| 12:00 PM | West Virginia @ 5 Oklahoma | FOX | Gus Johnson, Joel Klatt |
| 12:00 PM | 9 Florida @ South Carolina | ESPN | Dave Pasch, Greg McElroy, Tom Luginbill |
| 12:00 PM | Purdue @ 23 Iowa | ESPN2 | Beth Mowins, Anthony Becht, Rocky Boiman |
| 12:00 PM | Iowa State @ Texas Tech | FS1 | Brian Custer, Robert Smith |
| 12:00 PM | Houston @ Connecticut | ESPNU | Mike Corey, Rene Ingoglia |
| 12:00 PM | 11 Auburn @ Arkansas | SECN | Taylor Zarzour, Matt Stinchcomb |
| 12:00 PM | 6 Wisconsin @ Illinois | BTN | Kevin Kugler, Matt Millen |
| 12:00 PM | Georgia Tech @ Miami | ACCN | Wes Durham, Roddy Jones, Eric Wood |
| 12:00 PM | Kent State @ Ohio | CBSSN | Dave Ryan, Corey Chavous |
| 12:00 PM | N.C. State @ Boston College | ACC RSNs | Evan Lepler, Dave Archer |
| 2:00 PM | Toledo @ Ball State | ESPN+ | |
| 2:00 PM | Central Michigan @ Bowling Green | ESPN3 | |
| 2:30 PM | Oregon State @ California | P12N | Kate Scott, Chad Brown |
| 2:30 PM | TCU @ Kansas State | FSN regional | Justin Kutcher, Petros Papadakis, Shane Vereen |
| 2:30 PM | Northern Illinois @ Miami (OH) | ESPN+ | |
| 3:00 PM | New Mexico @ Wyoming | AT&T Sports (RM, SW) | Drew Goodman, Sed Bonner |
| 3:00 PM | Coastal Carolina @ Georgia Southern | ESPN3 | |
| 3:30 PM | 12 Oregon @ 25 Washington | ABC | Sean McDonough, Todd Blackledge |
| 3:30 PM | 2 LSU @ Mississippi State | CBS | Brad Nessler, Gary Danielson |
| 3:30 PM | Temple @ 19 Southern Methodist | ESPN2 | Mark Jones, Dusty Dvoracek |
| 3:30 PM | Tulsa @ 21 Cincinnati | ESPNU | Kevin Brown, Andre Ware |
| 3:30 PM | 20 Minnesota @ Rutgers | BTN | Lisa Byington, J Leman |
| 3:30 PM | Indiana @ Maryland | BTN | Mike Monaco, Stanley Jackson |
| 3:30 PM | Duke @ Virginia | ACCN | Chris Cotter, Mark Herzlich |
| 3:30 PM | South Florida @ Navy | CBSSN | John Sadak, Randy Cross |
| 3:30 PM | North Carolina @ Virginia Tech | ACC RSNs | Tom Werme, James Bates |
| 3:30 PM | Southern Mississippi @ Louisiana Tech | NFLN | Rhett Lewis, Ben Leber |
| 3:30 PM | ULM @ 24 Appalachian State | ESPN+ | |
| 3:30 PM | Buffalo @ Akron | ESPN3 | |
| 4:00 PM | 18 Baylor @ Oklahoma State | FOX | Tim Brando, Spencer Tillman |
| 4:00 PM | 22 Missouri @ Vanderbilt | SECN | Dave Neal, DJ Shockley |
| 4:00 PM | Middle Tennessee @ North Texas | Stadium | |
| 4:00 PM | Charlotte @ Western Kentucky | ESPN+ | |
| 4:00 PM | Old Dominion @ UAB | ESPN+ | |
| 6:00 PM | Kentucky @ 10 Georgia | ESPN | Jason Benetti, Rod Gilmore, Quint Kessenich |
| 6:00 PM | 17 Arizona State @ 13 Utah | P12N | Ted Robinson, Yogi Roth |
| 6:00 PM | Maine @ Liberty | ESPN+ | |
| 6:00 PM | Rice @ UTSA | ESPN3 | |
| 7:00 PM | Tulane @ Memphis | ESPN2 | Anish Shroff, John Congemi |
| 7:00 PM | Colorado @ Washington State | ESPNU | Roy Philpott, Kelly Stouffer |
| 7:00 PM | East Carolina @ UCF | CBSSN | Ben Holden, Ross Tucker |
| 7:00 PM | Kansas @ 15 Texas | Longhorn Network | Lowell Galindo, Ahmad Brooks |
| 7:00 PM | San Diego State @ San Jose State | Stadium (Facebook) | |
| 7:00 PM | Army @ Georgia State | ESPN+ | |
| 7:00 PM | UTEP @ FIU | ESPN+ | |
| 7:00 PM | Western Michigan @ Eastern Michigan | ESPN+ | |
| 7:30 PM | 16 Michigan @ 7 Penn State | ABC | Chris Fowler, Kirk Herbstreit |
| 7:30 PM | Texas A&M @ Ole Miss | SECN | Tom Hart, Jordan Rodgers, Cole Cubelic |
| 7:30 PM | Florida State @ Wake Forest | ACCN | Dave O’Brien, Tim Hasselbeck |
| 9:00 PM | Tennessee @ 1 Alabama | ESPN | Steve Levy, Brian Griese, Todd McShay |
| 9:30 PM | Arizona @ USC | P12N | Roxy Bernstein, Anthony Herron |
| 10:15 PM | 14 Boise State @ BYU | ESPN2 | Clay Matvick, Ryan Leaf |
| 10:15 PM | Nevada @ Utah State | ESPNU | Mike Couzens, Kirk Morrison |
| 11:00 PM | Air Force @ Hawaii | CBSSN | Rich Waltz, Aaron Murray |
