| 12:00 PM | 19 Virginia Tech @ 8 North Carolina | ABC | Bob Wischusen, Dan Orlovsky |
| 12:00 PM | Oklahoma vs 22 Texas
(in Dallas) | FOX | Gus Johnson, Joel Klatt |
| 12:00 PM | 4 Florida @ 21 Texas A&M | ESPN/ESPNU | Dave Pasch, Greg McElroy |
| 12:00 PM | ULM @ Liberty | ESPN2 | Mike Couzens, Jay Walker |
| 12:00 PM | 17 LSU @ Missouri | SECN (alt) | Dave Flemming, Andre Ware, Quint Kessenich |
| 12:00 PM | Coastal Carolina @ 23 ULL | POSTPONED | |
| 12:00 PM | South Carolina @ Vanderbilt | SECN | Dave Neal, DJ Shockley |
| 12:00 PM | N.C. State @ Virginia | ACCN | Wes Durham, Tim Hasselbeck |
| 12:30 PM | Duke @ Syracuse | ACC RSNs | Tom Werme, James Bates |
| 1:30 PM | Citadel @ Army | CBSSN | Ben Holden, Ross Tucker |
| 3:30 PM | Texas Tech @ 24 Iowa State | ABC | Mark Jones, Dusty Dvoracek |
| 3:30 PM | 14 Tennessee @ 3 Georgia | CBS | Brad Nessler, Gary Danielson |
| 3:30 PM | UTSA @ 15 BYU | ESPN2 | Anish Shroff, Tom Luginbill |
| 3:30 PM | Central Arkansas @ Arkansas State | ESPN3 | |
| 3:30 PM | Texas State @ Troy | ESPN3 | |
| 4:00 PM | Kansas State @ TCU | FOX | Tim Brando, Spencer Tillman |
| 4:00 PM | Arkansas @ 13 Auburn | ESPN | Taylor Zarzour, Matt Stinchcomb |
| 4:00 PM | Middle Tennessee @ Florida International | ESPNU | Clay Matvick, Rocky Boiman |
| 4:00 PM | Pittsburgh @ Boston College | ACCN | Chris Cotter, Mark Herzlich |
| 4:00 PM | Florida Atlantic @ Southern Mississippi | POSTPONED | |
| 6:00 PM | Temple @ Navy | CBSSN | John Sadak, Randy Cross |
| 7:00 PM | East Carolina @ South Florida | ESPN+ | Lincoln Rose, Stanford Routt |
| 7:30 PM | 7 Miami @ 1 Clemson | ABC | Chris Fowler, Kirk Herbstreit |
| 7:30 PM | Florida State @ 5 Notre Dame | NBC | Paul Burmeister, Tony Dungy |
| 7:30 PM | 2 Alabama @ Ole Miss | ESPN | Sean McDonough, Todd Blackledge, Todd McShay |
| 7:30 PM | UTEP @ Louisiana Tech | ESPN2 | Dave O'Brien, Mike Golic |
| 7:30 PM | Mississippi State @ Kentucky | SECN | Tom Hart, Jordan Rodgers, Cole Cubelic |
| 7:30 PM | Marshall @ Western Kentucky | Stadium RSNs | Chris Hassel, A.J. Hawk |
| 8:00 PM | Charlotte @ North Texas | ESPNU | Roy Philpott, Kelly Stouffer |
